.dg{--dg-paper: #ffffff;--dg-ink: #003c68;--dg-ink-soft: #5b7a94;--dg-line: rgba(0, 60, 104, .22);--dg-line-soft: rgba(0, 60, 104, .12);--dg-cyto-fill: #f4f9fc;--dg-cyto-line: rgba(0, 60, 104, .18);--dg-mito-fill: #fdf6ec;--dg-mito-line: #d9a441;--dg-er-fill: #f5f2fb;--dg-er-line: #a78bda;--dg-mol-fill: #ffffff;--dg-mol-line: #9db6c9;--dg-mol-ink: #003c68;--dg-hub-fill: #003c68;--dg-hub-ink: #ffffff;--dg-entry-fill: #eef5f9;--dg-catabolic: #0e7490;--dg-anabolic: #2f6f57;--dg-committed: #b23b4e;--dg-atp: #b45309;--dg-atp-bg: #fef3c7;--dg-nadh: #0e7490;--dg-nadh-bg: #cffafe;--dg-fadh2: #6d28d9;--dg-fadh2-bg: #ede9fe;--dg-gtp: #0f766e;--dg-gtp-bg: #ccfbf1;--dg-co2: #475569;--dg-co2-bg: #eef2f6;--dg-cost: #b91c1c;--dg-cost-bg: #fee2e2;--dg-chart-a: #b45309;--dg-chart-b: #0891b2;--dg-chart-c: #6d28d9;margin:1.9rem 0;border:1px solid var(--line);border-radius:var(--radius-lg);background:var(--panel);overflow:hidden}.book-layout[data-theme=dark] .dg{--dg-paper: #16202b;--dg-ink: #e2eef6;--dg-ink-soft: #93aec4;--dg-line: rgba(190, 220, 240, .3);--dg-line-soft: rgba(190, 220, 240, .16);--dg-cyto-fill: #1a2735;--dg-cyto-line: rgba(190, 220, 240, .22);--dg-mito-fill: #2b2519;--dg-mito-line: #b98c3c;--dg-er-fill: #241f33;--dg-er-line: #8a72c4;--dg-mol-fill: #1e2c3a;--dg-mol-line: #4e6c86;--dg-mol-ink: #e2eef6;--dg-hub-fill: #4fb8d8;--dg-hub-ink: #06202c;--dg-entry-fill: #24313f;--dg-catabolic: #5eead4;--dg-anabolic: #86efac;--dg-committed: #fca5a5;--dg-atp: #fbbf24;--dg-atp-bg: rgba(251, 191, 36, .18);--dg-nadh: #67e8f9;--dg-nadh-bg: rgba(103, 232, 249, .16);--dg-fadh2: #c4b5fd;--dg-fadh2-bg: rgba(196, 181, 253, .16);--dg-gtp: #5eead4;--dg-gtp-bg: rgba(94, 234, 212, .16);--dg-co2: #cbd5e1;--dg-co2-bg: rgba(203, 213, 225, .12);--dg-cost: #fca5a5;--dg-cost-bg: rgba(252, 165, 165, .16);--dg-chart-a: #d97706;--dg-chart-b: #0891b2;--dg-chart-c: #8b5cf6}.dg__head{display:flex;align-items:baseline;justify-content:space-between;gap:.75rem;flex-wrap:wrap;padding:.85rem 1.1rem .7rem;border-bottom:1px solid var(--line);background:var(--bg-soft)}.dg__title{font-size:.95rem;font-weight:800;color:var(--ink);letter-spacing:-.01em;margin:0}.dg__kicker{font-size:.68rem;font-weight:800;text-transform:uppercase;letter-spacing:.09em;color:var(--ink-soft)}.dg__rail{overflow-x:auto;overflow-y:hidden;padding:1rem 1.1rem;-webkit-overflow-scrolling:touch;scrollbar-width:thin}.dg__canvas{display:block;margin:0 auto;width:100%;height:auto;max-width:100%}.dg--wide .dg__canvas{min-width:var(--dg-minw, 640px)}.dg__hint{display:none;padding:0 1.1rem .7rem;font-size:.72rem;color:var(--ink-soft);font-weight:600}@media(max-width:720px){.dg--wide .dg__hint{display:block}}.dg__caption{padding:.85rem 1.1rem;border-top:1px solid var(--line);background:var(--bg-soft);font-size:.85rem;line-height:1.55;color:var(--ink-soft)}.dg__caption strong{color:var(--ink)}.dg__legend{display:flex;flex-wrap:wrap;gap:.4rem .9rem;padding:0 1.1rem .9rem}.dg__key{display:inline-flex;align-items:center;gap:.35rem;font-size:.73rem;font-weight:600;color:var(--ink-soft)}.dg__swatch{width:.7rem;height:.7rem;border-radius:3px;flex:none;border:1px solid var(--dg-line)}.dg__swatch--hub{background:var(--dg-hub-fill);border-color:var(--dg-hub-fill);border-radius:999px}.dg__swatch--mol{background:var(--dg-mol-fill);border-color:var(--dg-mol-line)}.dg__swatch--atp{background:var(--dg-atp-bg);border-color:var(--dg-atp)}.dg__swatch--nadh{background:var(--dg-nadh-bg);border-color:var(--dg-nadh)}.dg__swatch--fadh2{background:var(--dg-fadh2-bg);border-color:var(--dg-fadh2)}.dg__swatch--co2{background:var(--dg-co2-bg);border-color:var(--dg-co2)}.dg__swatch--mito{background:var(--dg-mito-fill);border-color:var(--dg-mito-line)}.dg__swatch--cyto{background:var(--dg-cyto-fill);border-color:var(--dg-cyto-line)}.dg__swatch--committed{background:var(--dg-committed);border-color:var(--dg-committed)}.dg__swatch--anabolic{background:var(--dg-anabolic);border-color:var(--dg-anabolic)}.dg__swatch--chart-a{background:var(--dg-chart-a);border-color:var(--dg-chart-a)}.dg__swatch--chart-b{background:var(--dg-chart-b);border-color:var(--dg-chart-b)}.dg__swatch--chart-c{background:var(--dg-chart-c);border-color:var(--dg-chart-c)}.dg 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path.is-live{animation:dg-flux-move 2.6s linear infinite;opacity:1}:root[data-diagram-motion=on] .dg.is-walking .dg-flux path.is-live.is-reverse{animation-name:dg-flux-move-rev}:root[data-diagram-motion=on] .dg.is-walking .dg-flux path.is-live.is-slow{animation-duration:4.2s}:root[data-diagram-motion=on] .dg.is-walking .dg-flux path.is-live.is-fast{animation-duration:1.7s}.dg-a-sweep{fill:none;stroke:var(--dg-catabolic);stroke-width:4.5;stroke-linecap:round;opacity:0;animation:dg-sweep 3.6s linear infinite}@keyframes dg-sweep{0%{stroke-dashoffset:var(--len, 300);opacity:0}8%,82%{opacity:.9}to{stroke-dashoffset:0;opacity:0}}.dg-a-hbond{animation:dg-hbond 2.6s ease-in-out infinite}@keyframes dg-hbond{0%,to{opacity:.28}45%{opacity:1}}.dg-a-tuck{animation:dg-tuck 5.4s ease-in-out infinite}@keyframes dg-tuck{0%,to{transform:translate(0)}42%,52%{transform:translate(var(--dx, 0px),var(--dy, 0px))}}.dg-a-join{animation:dg-join 6s ease-in-out infinite}@keyframes 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.dg__steps{display:flex}.dg__progress{display:none;height:2px;background:var(--line);overflow:hidden}.dg.is-walking .dg__progress{display:block}.dg__progress i{display:block;height:100%;width:0;background:var(--accent);transition:width .38s var(--ease-out)}@media(prefers-reduced-motion:reduce){.dg__progress i{transition:none}}.dg__stepnum{flex:none;display:inline-flex;align-items:center;justify-content:center;min-width:1.6rem;height:1.6rem;padding:0 .4rem;border-radius:999px;background:var(--accent);color:#fff;font-size:.72rem;font-weight:800;font-variant-numeric:tabular-nums}.dg__steptext{flex:1 1 16rem;font-size:.86rem;line-height:1.5;color:var(--ink);margin:0}.dg__steptext b{font-weight:700}.dg__tools{display:none}.dg.is-interactive .dg__tools{display:flex}@media print{.dg{break-inside:avoid}.dg__rail{overflow:visible}.dg__tools,.dg__spot,.dg__steps{display:none!important}.dg-flux path{animation:none;opacity:.3}}.atlas__bar{display:flex;align-items:center;gap:.5rem;flex-wrap:wrap;padding:.6rem 1.1rem;border-bottom:1px solid var(--line)}.atlas__bar-gap{flex:1 1 auto}.atlas__crumb{margin:0;font-size:.8rem;font-weight:700;color:var(--ink);letter-spacing:-.01em}.atlas__btn{display:inline-flex;align-items:center;gap:.3rem;padding:.32rem .7rem;border:1px solid var(--line);border-radius:999px;background:var(--panel);color:var(--ink-soft);font:inherit;font-size:.73rem;font-weight:700;cursor:pointer;transition:color var(--motion-fast, .15s) ease,border-color var(--motion-fast, .15s) ease}.atlas__btn:hover:not(:disabled){color:var(--brand);border-color:var(--brand)}.atlas__btn:disabled{opacity:.4;cursor:default}.atlas__stage{position:relative;width:100%;aspect-ratio:4 / 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#0000002e;transform:translateY(-1px)}.chapter-full-view-banner>svg{flex-shrink:0;color:var(--accent)}.chapter-full-view-banner__body{flex:1;display:flex;flex-direction:column;gap:.15rem;min-width:0}.chapter-full-view-banner__title{font-size:.98rem;font-weight:700;color:var(--ink)}.chapter-full-view-banner__subtitle{font-size:.85rem;color:var(--ink-soft);line-height:1.4}.chapter-full-view-banner__arrow{flex-shrink:0;font-size:1.1rem;color:var(--accent);font-weight:600;transition:transform var(--motion-fast) var(--ease-out)}.chapter-full-view-banner:hover .chapter-full-view-banner__arrow{transform:translate(2px)}.book-view-toggle--mobile{display:inline-flex;align-items:center;justify-content:center;width:32px;height:32px;border:none;background:transparent;color:var(--ink);border-radius:var(--radius-sm);text-decoration:none;transition:background var(--motion-fast) var(--ease-out),color var(--motion-fast) var(--ease-out)}.book-view-toggle--mobile:hover{background:var(--accent-soft);color:var(--accent)}.model-3d{margin:2rem 0;border-radius:var(--radius-lg);overflow:hidden;border:1px solid var(--line);background:#0a0a0f}.model-3d__viewer{position:relative;width:100%;padding-bottom:56.25%}.model-3d__viewer iframe{position:absolute;inset:0;width:100%;height:100%;border:none}.model-3d__caption{padding:.75rem 1rem;background:var(--panel);border-top:1px solid var(--line);font-size:.85rem;color:var(--ink-soft);display:flex;align-items:baseline;gap:.5rem}.model-3d__caption strong{color:var(--ink);font-weight:600}.model-3d__hint{margin-left:auto;font-size:.75rem;color:var(--ink-muted);white-space:nowrap}@media(max-width:640px){.model-3d__viewer{padding-bottom:75%}.model-3d__caption{flex-direction:column;gap:.25rem}.model-3d__hint{margin-left:0}}:root[data-theme=dark],.book-layout[data-theme=dark],.book-mobile-bar[data-theme=dark]{--bg: #0f1419;--bg-soft: #151b22;--panel: #1a2029;--panel-strong: #222a35;--ink: #e6edf3;--ink-soft: #9aa7b4;--line: rgba(255, 255, 255, .1);--brand: #6fb8d9;--brand-deep: #4a9cc2;--accent: #5ec8e8;--accent-soft: rgba(94, 200, 232, .18);--success: #6ee7b7;--error: #fca5a5;--shadow: 0 1px 4px rgba(0, 0, 0, .5);--callout-analogy-bg: #0e2a33;--callout-analogy-border: #1f6e84;--callout-analogy-label: #7ed5ec;--callout-mnemonic-bg: #1e1432;--callout-mnemonic-border: #6b3fa0;--callout-mnemonic-label: #c9a6ff;--callout-insight-bg: #2a1f0a;--callout-insight-border: #9a6c10;--callout-insight-label: #f5d89a;--callout-passage-peek-bg: #131a30;--callout-passage-peek-border: #3b5998;--callout-passage-peek-label: #b3c6f4;--callout-tip-bg: #0d2119;--callout-tip-border: #166534;--callout-tip-label: #86efac;--callout-must-memorize-bg: linear-gradient(135deg, #2a240a 0%, #1f1a05 100%);--callout-must-memorize-border: #eab308;--callout-must-memorize-shadow: 0 0 0 1px rgba(234, 179, 8, .25), 0 2px 12px rgba(234, 179, 8, .18);--callout-must-memorize-pill-bg: #eab308;--callout-must-memorize-pill-ink: #1a1205;--quiz-correct-bg: rgba(52, 211, 153, .12);--quiz-correct-border: #34d399;--quiz-correct-ink: #6ee7b7;--quiz-correct-highlight: rgba(110, 231, 183, .2);--quiz-incorrect-bg: rgba(248, 113, 113, .12);--quiz-incorrect-border: #f87171;--quiz-incorrect-ink: #fca5a5;--quiz-incorrect-highlight: rgba(252, 165, 165, .2);--quiz-score-ink: #fbbf24;--quiz-review-note-bg: rgba(245, 158, 11, .12);--quiz-review-note-border: #f59e0b;--quiz-review-note-ink: #fcd34d;--image-card-bg: #f5f0e6;--image-card-padding: .75rem;--image-caption-ink: #4a5568;--sidebar-backdrop: rgba(0, 0, 0, .6);--sidebar-shadow: 4px 0 24px rgba(0, 0, 0, .5);--hl-yellow: rgba(250, 204, 21, .28);--hl-green: rgba(74, 222, 128, .28);--hl-blue: rgba(96, 165, 250, .3);--hl-pink: rgba(244, 114, 182, .28)}::highlight(pmp-hl-yellow){background-color:var(--hl-yellow)}::highlight(pmp-hl-green){background-color:var(--hl-green)}::highlight(pmp-hl-blue){background-color:var(--hl-blue)}::highlight(pmp-hl-pink){background-color:var(--hl-pink)}.book-layout[data-theme=dark]{background:var(--bg);color:var(--ink)}.book-layout[data-theme=dark] .book-prose figure{background:var(--image-card-bg);padding:var(--image-card-padding) var(--image-card-padding) calc(var(--image-card-padding) - .25rem);border-radius:var(--radius-sm)}.book-layout[data-theme=dark] .book-prose figure figcaption{color:var(--image-caption-ink);background:transparent;padding-top:.5rem}.book-layout[data-theme=dark] .book-prose>p>img,.book-layout[data-theme=dark] .book-prose>img{background:var(--image-card-bg);padding:var(--image-card-padding);border-radius:var(--radius-sm)}.book-layout[data-theme=dark] .model-3d,.book-layout[data-theme=dark] .model-3d figure,.book-layout[data-theme=dark] .lightbox img{background:transparent;padding:0}.book-layout[data-theme=dark] .book-prose figure.dg{background:var(--panel);padding:0;border-radius:var(--radius-lg)}.book-layout[data-theme=dark] .book-prose figure.dg figcaption{color:var(--ink-soft);background:var(--bg-soft);padding:.85rem 1.1rem}.book-layout[data-theme=dark] .book-prose pre code{color:inherit}:root[data-theme=dark] .pmp-site-header{background:var(--panel);box-shadow:0 1px #ffffff0f}:root[data-theme=dark] .pmp-site-header.is-scrolled{background:#1a2029f5;box-shadow:0 6px 20px #00000073}:root[data-theme=dark] .pmp-topbar{background:var(--brand-deep);color:#fff}:root[data-theme=dark] .pmp-site-nav__link,:root[data-theme=dark] .pmp-site-nav__dropdown-trigger{color:var(--ink)}:root[data-theme=dark] .pmp-site-nav__link:hover,:root[data-theme=dark] .pmp-site-nav__link.is-active,:root[data-theme=dark] .pmp-site-nav__dropdown-trigger:hover,:root[data-theme=dark] .pmp-site-nav__dropdown-trigger.is-active,:root[data-theme=dark] .pmp-site-nav__dropdown.is-open .pmp-site-nav__dropdown-trigger{color:var(--accent);background:var(--accent-soft)}:root[data-theme=dark] .pmp-site-nav__dropdown-menu{background:var(--panel-strong);border-color:var(--line);box-shadow:0 20px 40px #00000080,0 0 0 1px #ffffff0a}:root[data-theme=dark] .pmp-site-nav__dropdown-item{color:var(--ink)}:root[data-theme=dark] .pmp-site-nav__dropdown-item:hover,:root[data-theme=dark] .pmp-site-nav__dropdown-item.is-active{background:var(--accent-soft);color:var(--accent)}:root[data-theme=dark] .pmp-site-nav__dropdown-item-desc{color:var(--ink-soft)}:root[data-theme=dark] .pmp-site-header__menu-button{color:var(--ink)}:root[data-theme=dark] .pmp-site-header__menu-icon span{background:var(--ink)}:root[data-theme=dark] .pmp-site-footer{background:var(--panel);border-top-color:var(--line)}:root[data-theme=dark] .pmp-site-footer__column a,:root[data-theme=dark] .pmp-site-footer__social a,:root[data-theme=dark] .pmp-site-footer__bottom-links a{color:var(--ink-soft)}:root[data-theme=dark] .pmp-site-footer__column a:hover,:root[data-theme=dark] .pmp-site-footer__social a:hover,:root[data-theme=dark] .pmp-site-footer__bottom-links a:hover{color:var(--accent)}:root[data-theme=dark] .pmp-site-header,:root[data-theme=dark] .pmp-topbar,:root[data-theme=dark] .pmp-site-footer,.pmp-site-header,.pmp-topbar,.pmp-site-footer{transition:background-color var(--motion-fast) var(--ease-out),color var(--motion-fast) var(--ease-out),border-color var(--motion-fast) var(--ease-out)}.book-layout,.book-mobile-bar,.book-layout__sidebar,.book-layout__toc,.book-content,.book-prose pre,.callout,.flashcard,.section-quiz__question,.section-quiz__option label,.book-theme-toggle{transition:background-color var(--motion-fast) var(--ease-out),border-color var(--motion-fast) var(--ease-out),color var(--motion-fast) var(--ease-out)}body:has(.book-layout){--book-chrome-progress: 0}body:has(.book-layout) .pmp-site-header,body:has(.book-layout) .book-mobile-bar{transform:translateY(calc(var(--book-chrome-progress, 0) * -100%));opacity:calc(1 - var(--book-chrome-progress, 0));will-change:transform,opacity}body.book-chrome-faded .pmp-site-header,body.book-chrome-faded .book-mobile-bar{pointer-events:none}body:has(.book-layout) .book-layout__sidebar,body:has(.book-layout) .book-layout__toc{top:calc(var(--site-header-height, 0px) * (1 - var(--book-chrome-progress, 0)));height:calc(100vh - var(--site-header-height, 0px) * (1 - var(--book-chrome-progress, 0)))}@media(max-width:900px){body:has(.book-layout) .book-layout__sidebar{top:calc((var(--site-header-height, 0px) + var(--book-toolbar-height, 0px)) * (1 - var(--book-chrome-progress, 0)));height:calc(100dvh - (var(--site-header-height, 0px) + var(--book-toolbar-height, 0px)) * (1 - var(--book-chrome-progress, 0)))}}@media(min-width:901px){:root[data-reader-mode=on] .book-layout__sidebar,:root[data-reader-mode=on] .book-layout__toc{opacity:0;pointer-events:none;overflow:hidden}:root[data-reader-mode=on] .book-content{max-width:980px;margin:0 auto}:root[data-reader-mode=on] .book-prose{font-size:1.1rem;line-height:1.8}}@media(min-width:1201px){:root[data-reader-mode=on] .book-layout{grid-template-columns:0fr 1fr 0fr;max-width:none}}@media(min-width:901px)and (max-width:1200px){:root[data-reader-mode=on] .book-layout{grid-template-columns:0fr 1fr;max-width:none}}::view-transition-old(root),::view-transition-new(root){animation-duration:.32s;animation-timing-function:cubic-bezier(.4,0,.2,1)}.book-reader-exit{position:fixed;top:calc(var(--site-header-height, 0px) * (1 - var(--book-chrome-progress, 0)) + .75rem);right:1rem;z-index:90;display:none;align-items:center;gap:.4rem;padding:.45rem .85rem;font:inherit;font-size:.85rem;color:var(--ink);background:var(--panel);border:1px solid var(--line);border-radius:999px;box-shadow:0 6px 20px #00000014;cursor:pointer;transition:background-color var(--motion-fast) var(--ease-out),color var(--motion-fast) var(--ease-out),top .24s var(--ease-out),transform var(--motion-fast) var(--ease-out)}.book-reader-exit:hover{color:var(--accent);transform:translateY(-1px)}:root[data-reader-mode=on] .book-reader-exit{display:inline-flex}.page-toc__control--reader[aria-pressed=true]{color:var(--accent);background:var(--panel)}